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However, during Will's presentation for the drug, Bright Eyes is forced from her cage, goes on a rampage, and is shot to death.

ALZ-112 is given to a chimpanzee named Bright Eyes, greatly increasing her intelligence. In San Francisco, pharmaceutical chemist William Rodman is testing the viral-based drug ALZ-112 on chimpanzees at the biotech company Gen-Sys to find a cure for Alzheimer's disease. It helped relaunch the franchise, and was followed by the sequel films Dawn of the Planet of the Apes (2014) and War for the Planet of the Apes (2017), while a fourth film is in development. Rise of the Planet of the Apes was also a commercial success, grossing over $481 million, and received numerous awards and nominations, including an Academy Award nomination for Best Visual Effects. The film received positive reviews from critics, with praise for Wyatt's direction, visual effects, and Serkis' performance, which helped change perceptions on the recognition of acting through performance capture. Rise of the Planet of the Apes was theatrically released worldwide by 20th Century Fox on August 5, 2011. The apes were created using extensive visual effects and performance capture commissioned by Weta Digital. Production struggled until Franco, Serkis, and Wyatt were hired by late 2009, and principal photography commenced in July 2010 and finished that September, with filming locations including Vancouver, San Francisco, and Oahu. The film features homages and drew inspiration from previous entries, particularly Conquest of the Planet of the Apes (1972). Rise of the Planet of the Apes first entered development in 2006 when Jaffa and Silver wrote a screenplay and sold it to 20th Century Fox, the producers and distributors of the original franchise. In the film, Caesar, a chimpanzee genetically enhanced by William Rodman (Franco), leads an ape uprising against members of humanity. It stars Andy Serkis as Caesar, alongside James Franco, Freida Pinto, John Lithgow, Brian Cox, Tom Felton, and David Oyelowo. It is a reboot of the Planet of the Apes film franchise, and is based on the 1963 novel Planet of the Apes by Pierre Boulle. Rise of the Planet of the Apes is a 2011 American science fiction action film directed by Rupert Wyatt from a screenplay by Rick Jaffa and Amanda Silver.